Common side effects include: Nausea and vomiting, especially at the start of treatment Gastrointestinal discomfort, such as bloating, diarrhea, or constipation Injection site reactions like redness, swelling, or itching Loss of lean muscle mass along with fat loss Dysesthesia, which includes tingling and skin sensitivity, is reported in as many as 20.9% of patients on higher doses
Baseline CV comorbidities were assessed using data from any time before the index date, whereas non-CV comorbidities, medication use and disease severity scores (QuanCharlson Comorbidity Index and adapted Diabetes Complications Severity Index [aDCSI]) were assessed in the 12-month baseline period
The recent BMJ systematic review and meta-analysis that triggered many of these headlines is important and, frankly, not surprising to clinicians who understand obesity as a chronic, relapsing disease
Nature 560 , 107111 (2018)
GSHee enhances neuron survival, and stabilizes spinal cord blood flow after injury 70,71
No known adverse pharmacokinetic interaction has been identified between the two