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MOTS-c is a mitochondrial-derived peptide its encoded by mitochondrial DNA, not nuclear DNA

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Interact with neurotransmitter systems , possibly affecting serotonin, dopamine, and GABA signaling pathways

The FDA is slowly approving more drugs to treat obesity (defined as having a BMI of 30 or greater) but the current two approved GLP-1 agents for weight loss only are Wegovy and high-dose Saxenda

IGFBP-3 was identified to have anti-tumor effects by regulating multiple processes such as adhesion, motility, proliferation, and invasion of prostate cancer cells (143)

doi: 10.1016/j.plaphy.2015.10.028 48 Di SalvoL