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How GLP-1 Works Weight Loss In the central nervous system, GLP-1 receptors are located in the hypothalamus, which is involved in regulating food intake The reduced feelings of hunger were associated with an increase in functional connectivity of the nucleus tract with the hypothalamus GLP-1 directly stimulates POMC/CART neurons and indirectly inhibits neuropeptide Y (NPY) and agouti-related peptide (AgRP) to increase measures of satiety and decrease hunger Interested in a new lease on life

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