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Nature Reviews Neuroscience, 16(5), 305312

Conversely, lowering lactate levels or inhibiting lactate transport (MCT1/MCT4) can relieve immunosuppression and improve responses to immune checkpoint blockade in preclinical models and early translational studies, supporting rational combinations of lactate- or lactylation-targeting strategies with immunotherapy [170]

doi: 10.1105/tpc.104.023093 71 SharmaP.JhaA