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Oct 9: In a relatively rare move, the FDA went against the recommendation of one of its advisory committees, rejecting a bid by Alnylam to expand Onpattro (patisiran)s label to cardiomyopathy of transthyretin-mediated amyloidosis

These methods test the model on independent datasets to evaluate its performance in real-world scenarios

Dose reduction of disease/symptom control drugs may be appropriate if symptoms are mild or intermittent, but these should be discontinued if altogether ineffective

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The direct oxidation of thiol compounds by H 2 O 2 is a divalent event, initiated when a thiolate anion attacks an oxygen atom

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