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Typical doses range from 1,2001,500 mg daily across three divided doses

You can find genetic testing with various companies such as 23andme.com Its estimated that those with one mutation (heterozygous) decrease their ability to methylate by 30% and those with two mutations (homozygous) decrease their ability to methylate by 70%, making it virtually impossible to get adequate B12 from diet alone (19)

1,2 Risk factors include having a diagnosis of T1DM, being over the age of 40 or a woman, and having a 10+ year history of diabetes

Higher doses move to higher tiers as needed

141 Gradual increase in foods with soluble and insoluble fiber, such as prunes or other dried fruits, can be helpful