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The JMIR semaglutide surveillance paper lists sibutramine in the historical lineage of weight-loss drugs that illegal vendors resurrect when demand outruns legitimate supply

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In the STEP-UP trial, the 7.2 mg dose produced 20.7% weight loss at 72 weeks, much closer to Mounjaro 15 mg than the 2.4 mg dose tested in SURMOUNT-5

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In addition to its role in managing blood sugar levels, Ozempic has been found to have other beneficial effects on the body most notably with weight loss