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The only reliable contamination prevention is strict adherence to refrigerated storage (28C), aseptic needle technique, and discarding vials after 28 days regardless of appearance

Upon arrival, vials should be immediately transferred to a temperature-controlled environment

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Falagas ME, Kasiakou SK (2005) Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections

Clinical ophthalmology (Auckland, N.Z.), 1(3), 201207