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3.1 Genetic factors in the pathogenesis of vitiligo The earliest evidence implicating genetic factors in the pathogenesis of vitiligo was reported by Nath et al., in 1994 (Spritz and Andersen, 2017)

The concentrations in other tissues were lower than the average concentration in the plasma and are presented in the descending order as follows: intestinal tract, lung, gonad, skin, skeletal muscle, cardiac muscle, whole blood, brain, and body fat

Glutathione is known for its role in reducing free radical damage, promoting an even skin tone, and supporting collagen production

doi: 10.4162/nrp.2014.8.3.272, 39

The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx

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