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Dose escalation phase (titration) Tirzepatide titration (dose escalation) typically follows this schedule: Month 2: 4-6 mg once weekly Month 3: 6-8 mg once weekly Month 4: If tolerated, increase to 8-10 mg once weekly Month 5: If the dosage needs to be escalated further, increase to 10-12 mg once weekly Month 6 and onward: If the dosage needs to be escalated further, increase to 12-14 mg once weekly The maximum dosage is typically 14 mg once weekly if further glycemic control or weight loss is required

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[DOI] [PubMed] [Google Scholar] 115.Rye P, Modi R, Cawsey S, Sharma AM

GLP-1 Receptor agonists in diabetic kidney disease: from clinical outcomes to mechanisms