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Dehydroascorbate reductase affects leaf growth, development, and function

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PloS One (2013) 8(2):e56567

Notably, melatonin mediates the nuclear output of PGC1 by upregulating the expression of SIRT1 and increases the expression of mitochondrial biogenesis markers PGC1 and TFAM after melatonin treatment, thereby enhancing autophagy and mitochondrial health (Siddhi et al., 2022)

Although THC possesses neuroprotective antioxidant properties through non-CB1R pathways [33], it also upregulates plasma inflammatory cytokines [34], increases vulnerability to ischemic stroke in young people [35], increases mitochondrial dysfunction [36, 37] and alters gene pathways associated with mitochondrial oxidative phosphorylation [38]