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In previous studies, senescence chondrocytes were either from OA cartilage, or induced by other methods

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This means BPC-157 essentially makes tendon cells more responsive to the body natural growth signals, amplifying the healing response that already exists

GLP-1 agents, while costly and not yet guideline-endorsed for prevention, offer broader metabolic benefits without inherent bleeding risk

Quercetin can block the HMGB1/RAGE/NF-B axis to inhibit the release of pro-inflammatory factors such as TNF- and IL-6, target the NLRP3 inflammasome to block the maturation of IL-1/IL-18, and restore the balance of immune cell apoptosis by upregulating miR-204 to inhibit the HIF1/NFATc2 axis and the Src-STAT3-NFAT pathway (Rajabi et al., 2020