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GIP, the second target activated by tirzepatide and Retatrutide, adds complementary effects on insulin secretion and fat metabolism while also influencing reward pathways through distinct mechanisms

References: National Center for Biotechnology Information (2023)

May cause constipation if overused

You can speed up weight loss on Wegovy by combining it with other weight loss efforts, such as a low-calorie diet and increased exercise

Semaglutide, a GLP-1 receptor agonist that slows gastric emptying and suppresses appetite, works through a fundamentally different mechanism than phentermine, a sympathomimetic stimulant that increases heart rate and blood pressure

The first component of CONTRAVE, naltrexone HCI, is an opioid antagonist