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Acknowledgments The authors are grateful for the kind support provided by John Poulton, Susan Poulton, and Tabitha J

Research questions include whether GLP-3 affects body composition differently than GLP-1, potentially preserving more muscle mass during weight loss, if GLP-3 enhances fat oxidation and metabolic rate through distinct pathways, whether combining GLP-3 with GLP-1 approaches offers advantages over either alone, and how GLP-3 might benefit metabolic flexibility and long-term weight maintenance

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