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Sitohang IBS, et al

[DOI] [PubMed] [Google Scholar] 89

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Petersburg looked at the effects of epitalon on body weight, food consumption, and lifespan in female Swiss SHR mice

The clinical potential of this approach is underscored by the approval of istradefylline in Japan and the United States as an adjunct therapy for PD patients experiencing motor fluctuations, representing the most advanced A 2A receptor antagonists in clinical development [480482]

This occurs when ,-unsaturated compounds with double or triple carboncarbon bonds are added to a soft nucleophile, such as the thiol group of cysteine of GSH [16]