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AOD9604, when injected in saline, may be rapidly cleared from the joint due to uptake into local circulation, limiting its therapeutic effects

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doi:10.1002/biof.1094

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Circulating TMAO has been identified as a risk factor for various chronic conditions, including kidney disease, type 2 diabetes (T2DM), musculoskeletal disorders, and cancer (162)

The renoprotective effects were abolished following antibiotic-induced microbial depletion but were transferable via FMT, confirming a microbiota-dependent mechanism ( Figure 5 ) [96]