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A subsequent study identified the compound N-(4-(2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)phenyl)acetamide as a notable SARM1 inhibitor, which demonstrated significant efficacy in a mouse model of CIPN (Fig

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5E, F, Supplementary data 3)

Stymuluje pewne MMP niezbdne do fizjologicznej przebudowy uszkodzonej tkanki, jednoczenie hamujc nadaktywacj MMP, ktra przyczynia si do przewlekej degradacji macierzy skrnej obserwowanej przy fotostarzeniu

Peer-Reviewed and Technical Citations Coskun T, et al

Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo