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Using 3D electron microscopy in large-animal models (cats and nonhuman primates), Duncan and coworkers provided the first evidence of direct remyelination by mature OLGs (Duncan et al., in vivo two-photon video microscopy with longitudinal follow-up over several weeks subsequently made it possible to demonstrate unequivocally that surviving OLGs were able to generate new myelin sheaths after cuprizone-induced demyelination (Bacmeister et al., 2020), suggesting that it probably makes only a minor contribution to myelin repair, in particular conditions, such as during motor learning tasks

IM is traditional for rapid absorption

Use an insulated travel case with ice packs to maintain 2-8 degrees Celsius during transport

Because skin cells take roughly a month to regenerate, most people do not see changes for at least 4 to 8 weeks of consistent use

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