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The intestines and liver are anatomically and functionally interconnected, forming the so-called gut liver axis [101,102,103,104,105]

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Several preclinical studies have shown that Quer in the myocardium can enhance the GSH antioxidant system by regulating multiple upstream molecular targets, such as peroxisome proliferator-activated receptor-gamma (PPAR-), phosphatidylinositide 3-kinase (PI3K)/serine/threonine kinase (AKT), and Nrf2 [120, 123, 124]

We synthesized evidence from published clinical studies and economic analyses, comparing incremental cost-effectiveness ratios (ICERs) and cost per quality-adjusted life year across obesity severity classes, with particular consideration of implications for Koreas healthcare context