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Diarrhea on tirzepatide and semaglutide can occur, especially during dose increases

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Patients with a history of diabetic retinopathy should be monitored for progression of diabetic retinopathy Hypoglycemia: Patients receiving Ozempic or Rybelsus tablets in combination with an insulin secretagogue (e.g., sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia

However, they also recognize that side effects can vary from person to person

A light snack or empty stomach is often preferred by first-time users to minimize early side effects while the medication is still ramping up in your system