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Christopher Paddock (Centers for Disease Control and Prevention)

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Abstract Skin aging is a multifactorial biological process driven by the cumulative effects of oxidative stress, chronic low-grade inflammation, and progressive deterioration of barrier function

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The process is simple, painless, and typically takes less than an hour

In contrast, bilateral injection of an opioid receptor antagonist, naloxone (i.e., pharmacological inhibition of MOR in the PVN), significantly reversed the morphine-induced constipation in nave mice, compared to the vehicle-injected control group (Fig