Significantly elevated homocysteine has been observed in people suffering with cardiovascular disease, stroke, neurodegeneration (Nelson et al, 2016) and frailty in old age (Guaita et al, 2021) and elevated homocysteine is associated with a reduced blood flow to the small vessels in the brain (reduced microcirculation) (Hassan et al, 2004) which is an important connection because a reduced microcirculation may increase the risk of developing Alzheimers disease, amyotrophic lateral sclerosis (ALS) or Parkinsons disease (Erdener and Dalkara, 2019)
Consider that daily effects may not be significant
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Tight junction regulation, intestinal permeability, and mucosal immunity in gastrointestinal health and disease
(2020) Nucleotides cytidine and uridine associated with vitamin B12 vs B-complex vitamins in the treatment of low back pain: the NUBES study
4 Photo Credit: Freepik Vitamin E works synergistically with glutathione to protect cells from oxidative stress