This accumulation likely further contributes to blood vasculature dysfunction, as it has been shown that chronically elevated sodium levels can lead to endothelial glycocalyx dysfunction and inflammation (Schierke et al., 2017)
This is because monoclonal antibodies are much larger molecules than CGRP and have very limited ability to penetrate brain barriers
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Park J, Lee K, Kim K, Yi SJ (2022) The role of histone modifications: from neurodevelopment to neurodiseases
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