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Crucially, the community feedback is inconsistent a meaningful share of reports describe no noticeable effect at all in the first week, and a subset describe early adverse effects (headache, brain fog, irritability) rather than benefit
In general, knock-out of the S100A8 or S100A9 leads to skin hyperplasia and aggravation of psoriatic symptoms in mouse models (121123)
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Therefore, a comprehensive synthesis of available evidence is needed to clarify whether non-invasive routes provide efficacy comparable to intramuscular therapy