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For pharma stakeholders, this head-to-head competition highlights opportunities in market differentiation, patient segmentation, and clinical positioning

On the eraser side, FTO has emerged as a radiosensitization target: genetic and pharmacologic FTO blockade increased DNA damage (reduced RAD51 foci, impaired HR) and improved tumor control by radiotherapy in HNSCC modelswithout exacerbating mucositisindicating a widened therapeutic window (146)

Established pharmacological options including acamprosate, naltrexone, and nalmefene remain the evidence-based first-line treatments

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Jan 17 1997;40(2):137-145

Mosenzon O, Del Prato S, Schechter M, Leiter LA, Ceriello A, DeFronzo RA, et al