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Contrary to canonical doctrine, GSH depletion unexpectedly protects against MASLD by substantially decreasing hepatic lipogenesis and fibrosis without triggering an oxidative stress response

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For example: PPR inhibits cytochrome P450 enzymes, reducing metabolism of warfarins active metabolite (7-hydroxywarfarin) and potentially diminishing anticoagulant efficacy (91)

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In vitro studies reveal that CUR alone up-regulates CYP3A (but not CYP1A2), while combined CUR/QUE and warfarin up-regulates both CYP3A and CYP1A2, altering warfarin metabolism (93)

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