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102,125 In a study that included 113 military personnel exposed to loud noise, B12 deficiency was detected in 47% of those with tinnitus plus noise-induced hearing loss, 27% of those with noise-induced hearing loss only, and 19% of those with normal hearing, suggesting B12 deficiency may be associated with risk of developing tinnitus

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In addition, GLP-1 expression was down-regulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expressions of lipolysis and autophagy-related genes and proteins were also inhibited, such as ATGL, HSL, and hepatic lipase deficiency gene (LIPC), suggesting that GLP-1 expression is also regulated by FNDC5, and may also provide therapeutic targets for lipid metabolism-related diseases