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Members of the genus continued to dominate the community (above 85% relative abundance, for 2.34 10 7 , 1.87 10 7 , 1.24 10 7 cells mL 1 , at 10, 20 and 30 MPa respectively) when grown at pressures associated with the upper region of the sub-surface ocean of Europa (20 MPa to 30 MPa under an ice shell 20 to 30 km thick) (Vance et al., 2007)
Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable