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+2+8 C,

It is studied in adults with overweight or obesity (BMI 27 or higher in REDEFINE 1) and in adults with type 2 diabetes (REDEFINE 2 and REIMAGINE 2)

It directly stimulates pro-opiomelanocortin/cocaine-and-amphetamine-regulated transcript (POMC/CART) neurons and indirectly inhibits neuropeptide-Y/agouti-related protein (NPY/AgRP) neurons through GABA neurotransmission, reducing appetite and promoting weight loss [40]

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Both supplements promote health benefits regarding increasing blood flow