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Research indicates that Traditional Chinese Medicine (TCM) extracts (e.g., terpenoids, phenols, flavonoids, saponins, and alkaloids) can directly activate AMPK or regulate its upstream kinases (LKB1, CaMKK ) and downstream effectors (SIRT1, PPAR , Nrf2), thereby improving hepatic lipid accumulation, mitigating inflammatory damage, and delaying NAFLD progression