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however, ABHD5 lacks an active serine found in other ABHD family members (33), in which possibilities might include promoting access to the TAG core through remodeling of the phospholipid monolayer, or removal of reaction products

208 Human PGC-1 also interacts directly with RNA and with NXF1 (Nuclear RNA export factor 1) to promote nuclear export of co-activated transcripts, essential for age-related telomere maintenance

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Animal studies and a small intravenous healthy-volunteer study established GH-release pharmacology