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Early clinical studies can then adopt metabolically defined enrichment strategies and a small set of pre-specified pharmacodynamic endpoints linking target engagement to intratumoral lactate and tissue lactylation, while evaluating mechanism-based combinations, including immunotherapy, within adaptive designs [39]

To support safe, effective, and equitable use, there is a clear need for regular, population-level monitoringnot only of the prevalence and patterns of use, but also of access, appropriateness, health outcomes, and broader system impacts

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What precautions should be taken when applying L-carnitine topically

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