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it reduces cisplatin-induced hair cell loss, and protects auditory hair cells ( 3.1.4 Quercetin (QU) QU is a widely used natural flavonoid compound that can be an effective antioxidant against cisplatin ototoxicity.QU scavenges a variety of free radicals such as peroxides and superoxides, as well as inhibits xanthine oxidase, blocks lipid peroxidation, chelates transition metals, and reduces cytosolic calcium uptake ( 3.1.5 Phloridzin and rhizodendron Phloridzin and rhizoposide are the main flavonoid structural compounds of apple with antioxidant and anticancer effects ( 3.1.6 Rutin Rutin belongs to the vitamin P family and is a natural flavonol glycoside