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In the PCOS rat model induced by dehydroepiandrosterone, EVs from adipose derived mesenchymal stem cells (AMSC) and their derived EVs can be partially mediated by miR-21-5P, regulating liver glucose homeostasis by targeting B cell translocation gene 2 (BTG2), significantly alleviating multiple phenotypes of PCOS rats, including metabolic abnormalities, polycystic ovaries, and infertility ( 3.1.4 EVs regulate sugar and lipid metabolism and affect obesity Obesity promotes the development of PCOS, which in turn exacerbates obesity (Teede et al., 2023)