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When starting both therapies simultaneously or in close succession, distinguishing which medication causes side effects becomes challenging, potentially complicating management decisions

For example, NMN has research to support its ability to improve skin health and enhance aerobic capacity, which NR doesnt.37 4 Meanwhile, NR has research that shows it can improve biomarkers associated with neurodegenerative disease, which cant be said of NMN.30 If you wanted to boost NAD+ levels, improve aerobic capacity, and protect your brain with a single supplement, a combination of NMN and NR may be superior to either in isolation

doi: 10.1089/cmb.2012.0021, 10 BartlettD

It will be very hard to estimate the precise impact

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They may be purely epithelioid, purely spindled, or an admixture of shapes