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Clinical experience with phentermine is that it achieves an average weight loss of 10%, and Qsymia ~12%, or 20-25 pounds

However, evidence recommending their use is limited

Open-label means that both patients and researchers knew what medication was being given, which introduces the possibility of placebo and expectation effects

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By examining the mechanisms of action, preclinical studies, and clinical trials, we aim to elucidate the potential benefits and limitations of these pharmacological agents in the management of PTC

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