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ARA-290 has the strongest specific evidence for SFN, with human clinical trials demonstrating measurable nerve fiber regrowth in the cornea of SFN patients

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SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024

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