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R Like acetylation, methylation does not typically increase water solubility

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Results Age-related increased oxidative load in LECs was linked to progressive decline in Nrf2, Cat and Prdx6 expression To identify age-related changes in ROS production and the connection between expression of Prdx6 and its regulator Nrf2, an antioxidant defense pathway, we monitored the intracellular redox-state of primary hLECs of different ages cultured in 96 well plate by using H2-DCF-DA dye 8,43

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Liver Res 5:4552 Woodhead JL, Yang K, Oldach D, MacLauchlin C, Fernandes P, Watkins PB et al (2019) Analyzing the mechanisms behind macrolide antibiotic-induced liver injury using quantitative systems toxicology modeling