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In addition, this treatment may prove to be unsustainable in the longer term, Boswell added

There are no large randomized trials demonstrating clinically significant fat loss from this combination in otherwise healthy adults

Circulation 80 , 551563 (1989)

Retatrutide Side Effects by Dose and Timeline Lets take a look at how retatrutide side effects are affected by dosage and time

Flatulence (gas) This side effect can be embarrassing or uncomfortable, especially after meals

However, these observational studies have inherent limitations, including potential residual confounding (as some registries lack complete data on important cancer risk factors like smoking), selection bias, and the challenge of detecting rare events