When analysing trials with different durations separately, a statistically significant difference across groups was detected ( p = 0.01, Figure 2): a significant positive association of GLP1RA with the incidence of cancer was found in the trials lasting 52 weeks (MHOR 2.20, 95% CI [1.32, 3.64], p = 0.003, Figure 2), whereas the difference was not significant for trials with a duration between 53 and 103 weeks (MHOR 1.17, 95% CI [0.87, 1.56], Figure 2), and no difference was found between groups for trials lasting at least 104 weeks (MHOR 1.02, 95% CI [0.95, 1.10], Figure 2)
From a clinical standpoint, treating prediabetes with semaglutide isnt just reasonable
This leads to potentially stronger effects on blood glucose control and weight loss
They found that people taking semaglutide showed significant weight loss
Adems, indica que hasta la fecha no ha realizado estudios que muestren si es que, una vez que se decida dejar su consumo, produzca un efecto rebote
That can slow how the dose is used and is a known issue, particularly in women and larger patients where there is more tissue to pass through
