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1 As we age, our glutathione stores decrease meaning we are more susceptible to oxidative stress from free radical damage

Through the activation of NF- signaling, TNF- (tumor necrosis factor-) and IL-17 (interleukin-17) raise the expression of PD-L1 (programmed cell death protein 1) in LNCaP cells, hence promoting tumor cell motility and chemoresistance

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If selenium concentration reaches or exceeds 122 g/l in plasma, as in the top tertile of the Nutritional Prevention of Cancer trial ( Reference Duffield-Lillico, Reid and Turnbull 109 ) or is already 137 g/l in serum, as in SELECT ( Reference Lippman, Klein and Goodman 106 ) , supplementation should be avoided ( Reference Lippman, Klein and Goodman 106 Reference Stranges, Marshall and Natarajan 108 , Reference Kristal, Darke and Morris 110 )

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