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These disparities highlight the importance of considering biological sex as a critical factor in drug dosing and safety assessments

PLS-DA revealed partial separation between improved and non-improved patients ( Figure 4A ), consistent with differences in overall metabolite profiles

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It was designed to be a stable, blood-brain barrier-penetrant compound that activates the hepatocyte growth factor (HGF)/c-Met receptor system

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Follow-up analysis to rule out GLUT1-mediated uptake using the glucose analog 6-NBDG 34 , revealed a GLUT1-dependent deregulation of glucose metabolism in CD38-expressing CD4 + , but not CD8 + APP T cells (Supplementary Fig