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Below are research-focused sources discussing IGF-1 LR3s proposed effects, benefits, and potential side effects
Key Takeaways Mitochondrial Enhancement: MOTS-c peptide primarily works by boosting mitochondrial function, leading to improved cellular energy production and overall metabolic efficiency
It can, however, enhance exercise endurance and capacity in all age groups by increasing muscle carnitine levels and improving energy metabolism
IGF-1 LR3 is a synthetic analog of insulin-like growth factor-1 with amino acid substitutions at positions 3 and extended half-life (2030 hours vs 10 minutes for endogenous IGF-1), enabling systemic anabolic signaling without growth hormone involvement
This was attributed to the involvement of L-carnitine in mitochondrial transport of fatty acids thus its deficiency affects multiple organs including the smooth muscles in the gastrointestinal tract
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