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Dempsey reported that many of her patients with gut motility issues are doing fine on the low doses of the drug being used, and the mast cell paper reported that 9 of 14 of the patients in its case series with baseline nausea experienced reduced nausea after taking the drug

To understand how we are getting these longer-term effects, we need to study these drugs on a longer time scaleand thats exactly what we did. When the hormone GLP-1 finds a pancreatic beta cell, the ensuing chain of signals, proteins, and gene expression changes that lead to insulin secretion is very well documented

However, recent drug discoveries and targeted therapies indicate evidence for durable remissions but no guaranty can be given yet on drug resistance 2

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