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Urolithin A: sources, dosage and mechanism of action Urolithin A is a metabolite produced by the gut microbiota through the transformation of ellagitannins, a class of polyphenols commonly found in fruits such as pomegranates, raspberries, strawberries and nuts, especially walnuts

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Consistent with a role of activated T-cells in HEV neogenesis, combining anti-angiogenic therapy with anti-PD-L1 immunotherapy was sufficient to induce HEVs in several orthotopic and genetically engineered mouse models of cancer, stimulating tumor immunity [332]

BioTech Pharma website at Accessed March 5, 2026.

Moreover, the majority of these peptides do not penetrate deep within the skin and do not carry risks for systemic side effects [3, 16, 26, 30, 37]