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The addition of an acetyl group at the N-terminus enhances its stability, potency, and ability to cross the blood-brain barrier

Cheah KL, Norhayati MN, Husniati Yaacob L, et al

Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, et al

This complex catalyzes K6-linked polyubiquitination of PAICS, which in turn recruits UBAP2, triggering liquid-liquid phase separation and subsequent purinosome assembly

Vitamin C is commonly paired with glutathione because it helps support antioxidant activity and may help maintain glutathione levels in the body

Interestingly, the generation of ROS is increased in HGPS fibroblasts (Viteri et al., 2010) and this phenomenon is similar to normal aged fibroblasts