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Conflict of interests Professor Hanefeld has received speaking honoraria from Bayer Healthcare AG

The newly synthesized IGF-I is then hypothesized to be released into the circulation, where it may act upon various target tissues

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Weaknesses: Emerging Evidence for GIP Receptor Agonists: Evidence for therapeutic use of GIP is less established compared to GLP-1

10.1111/j.1742-1241.2011.02656.x Summary Keywords incretin hormones, GLP-1 receptor agonists, DPP-4 inhibitors, cardiovascular outcomes trials, clinical trials, incretin biology, type 2 diabetes Citation Gilbert MP and Pratley RE (2020) GLP-1 Analogs and DPP-4 Inhibitors in Type 2 Diabetes Therapy: Review of Head-to-Head Clinical Trials