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For most older adults with mild-to-moderate deficiency, no, high-dose oral or sublingual B12 corrects deficiency as well as injections in randomized trials

Injections are best for: Severe deficiencies, pernicious anemia, significant malabsorption issues, and when rapid symptom relief is needed

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As a result, lower drug administration requirements are feasible [17], so no modification of the therapeutic agent nor coupling the drug to any carrier is required [11]

For more information see, 42 U.S.C