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Leucine-, arginine-, and methionine-derived SAM can bind their sensors during high intracellular concentrations, thereby disrupting the interaction of the sensors with GATOR1/2, relieving the inhibition of GATOR complex, and activating mTORC1

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Glutathione precursors offer an alternative approach by providing the building blocks for the body's own glutathione synthesis

In this context, oxidative stress plays a significant role by increasing ROS levels in renal cells, which damages lipids, proteins, and DNA

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