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The FDA's 2022 guidance on surrogate endpoints in musculoskeletal diseases accepts dual-energy X-ray absorptiometry lean mass combined with functional measures (grip strength, chair-stand test) as co-primary endpoints 22

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The identification of these dichotomous astrocytic states, particularly the reparative A2 phenotype, has revealed promising therapeutic targets that will be examined in later sections of this review

Lassgue B, Clempus RE

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They will determine if you have a deficiency and prescribe the correct dosage